One-pot three-component reaction for the synthesis of alpha-(aminoethyl)-alpha,beta-enones.
作者信息
Bertozzi Fabio, Gustafsson Magnus, Olsson Roger
机构信息
Discovery Chemistry, ACADIA Pharmaceuticals A/S, Fabriksparken 58, DK-2600 Glostrup, Denmark.
出版信息
Org Lett. 2002 Nov 28;4(24):4333-6. doi: 10.1021/ol026976t.
PMID:12443091
Abstract
[reaction: see text] The synthesis of alpha-substituted alpha,beta-enones by a new metal iodide-promoted one-pot three-component reaction involving commercially available cyclopropyl ketones, aldehydes, and secondary amines followed by base treatment is described.
摘要
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