Hendricks Anke, Schuberth Hans-Joachim, Schueler Karen, Lloyd David H
Dermatology Unit, Department of Veterinary Clinical Studies, Royal Veterinary College, London, UK.
Res Vet Sci. 2002 Dec;73(3):273-7. doi: 10.1016/s0034-5288(02)00107-8.
This preliminary study investigated the potential role of staphylococcal superantigens in the pathogenesis of canine pyoderma. The staphylococcal enterotoxins A (SEA), SEB, SEC and SED, and the toxic shock syndrome toxin-1 (TSST-1) were assayed in isolates from skins of dogs with pyoderma. Culture supernatants from 25 of 96 isolates were positive for multiple superantigens, with SEA and SEC being the most frequently detected. In in vitro stimulation of canine peripheral blood mononuclear cells and quantitative flow cytometry revealed that low concentrations of SEA and SEB were potent stimulators of blastogenesis of T cells.
这项初步研究调查了葡萄球菌超抗原在犬脓皮病发病机制中的潜在作用。对患有脓皮病的犬只皮肤分离株检测了葡萄球菌肠毒素A（SEA）、SEB、SEC和SED以及中毒性休克综合征毒素-1（TSST-1）。96株分离株中有25株的培养上清液对多种超抗原呈阳性，其中SEA和SEC是最常检测到的。在对犬外周血单个核细胞的体外刺激和定量流式细胞术显示，低浓度的SEA和SEB是T细胞母细胞化的有效刺激物。
