Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids: key intermediates for H3 histamine receptor ligands.
作者信息
Braña Miguel F, Guisado Cristina, Fernando Alguacil Luis, Garrido Elisa, Pérez-García Carmen, Ruiz-Gayo Mariano
机构信息
Departamento de Ciencias Qui;micas, Sección de Qui;mica Orgánica y Farmacéutica, Universidad San Pablo CEU, Urb Montepríncipe, Boadilla del Monte 28668, Madrid, Spain.
出版信息
Bioorg Med Chem Lett. 2002 Dec 16;12(24):3561-3. doi: 10.1016/s0960-894x(02)00793-x.
Abstract
A new synthetic methodology to provide cis-2-(1H-imidazol-4-yl)-cyclopropane carboxylic acids is described. These cyclopropanes are useful for the preparation of novel H(3) receptor agents.
摘要
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