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本文引用的文献

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Acta Pharmacol Sin. 2000 Aug;21(8):673-9.
2
G-2964A and C734A genetic polymorphisms of CYP1A2 in Chinese population.
Acta Pharmacol Sin. 2000 Nov;21(11):1031-4.
3
Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2.体内血浆咖啡因代谢物比率（17X/137X）与人类CYP1A2的G-2964A和C734A多态性相关。
Pharmacogenetics. 2001 Jul;11(5):429-35. doi: 10.1097/00008571-200107000-00006.
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Individual and ethnic differences in CYP2C19 activity in Chinese populations.
Acta Pharmacol Sin. 2000 Mar;21(3):193-9.
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Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population.中国人群中CYP1A2活性的表型多态性及性别相关差异
Br J Clin Pharmacol. 2000 Feb;49(2):145-51. doi: 10.1046/j.1365-2125.2000.00128.x.
6
Detection of three genetic polymorphisms in the 5'-flanking region and intron 1 of human CYP1A2 in the Japanese population.日本人群中人类CYP1A2基因5'-侧翼区和内含子1的三种基因多态性检测
Jpn J Cancer Res. 1999 Sep;90(9):899-902. doi: 10.1111/j.1349-7006.1999.tb00832.x.
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Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine.利用咖啡因检测细胞色素P450 CYP1A2基因内含子1中C→A多态性的功能意义。
Br J Clin Pharmacol. 1999 Apr;47(4):445-9. doi: 10.1046/j.1365-2125.1999.00898.x.
8
Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans.人类CYP1A2基因5'侧翼区的基因多态性：对人类CYP1A2诱导性的影响。
J Biochem. 1999 Apr;125(4):803-8. doi: 10.1093/oxfordjournals.jbchem.a022352.
9
The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin.奥美拉唑预处理对S-美芬妥因快速和慢速代谢者对乙酰氨基酚代谢的影响。
Clin Pharmacol Ther. 1997 Jul;62(1):21-8. doi: 10.1016/S0009-9236(97)90148-X.
10
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test.尿代谢物比率表明奥美拉唑治疗后咖啡因代谢加速：与血浆清除率及呼气试验结果相符。
Clin Pharmacol Ther. 1994 Apr;55(4):402-11. doi: 10.1038/clpt.1994.49.

奥美拉唑在体内对CYP1A2的诱导作用与CYP1A2的基因多态性相关。

Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2.

作者信息

Han Xing-Mei, Ouyang Dong-Sheng, Chen Xiao-Ping, Shu Yan, Jiang Chang-Hong, Tan Zhi-Rong, Zhou Hong-Hao

机构信息

Pharmacogenetics Research Institute, Xiang-Ya School of Medicine, Central South University, Changsha, Hunan 410078, China.

出版信息

Br J Clin Pharmacol. 2002 Nov;54(5):540-3. doi: 10.1046/j.1365-2125.2002.01686.x.

DOI:10.1046/j.1365-2125.2002.01686.x
PMID:12445035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1874453/
Abstract

AIMS

To evaluate the effect of the CYP1A21C and CYP1A21F polymorphisms on the inducibility of CYP1A2 by omeprazole in healthy subjects.

METHODS

Mutations of CYP2C19 and CYP1A2 were identified by PCR-RFLP. Omeprazole, 120 mg day-1, was given to 12 extensive metabolizers (EM) with respect to CYP2C19 (six CYP1A21F/CYP1A21F and six CYP1A21C/CYP1A21F of CYP1A2) for 7 days. CYP1A2 activity was determined on three occasions, namely on day 1, day 9 and day 16 using the caffeine plasma index (the ratio of the concentrations of paraxanthine to caffeine), 6 h after oral administration of 200 mg caffeine.

RESULTS

There was a significant difference (P = 0.002) between the caffeine ratios for CYP1A21F/CYP1A21F and CYP1A21C/CYP1A21F genotypes on day 9, but not on day 1 or day 16 (P > 0.05). The changes in the ratios from day 9 to day 1 (48% +/- 20%vs 19% +/- 20%) and from day 9 to day 16 (50% +/- 31%vs 15% +/- 22%) were significantly different (P < 0.05) between the CYP1A21F/CYP1A21F and CYP1A21C/CYP1A21F genotypes.

CONCLUSION

The CYP1A21C and CYP1A21F genetic polymorphisms influenced the induction of CYP1A2 activity in vivo by omeprazole.

摘要

目的

评估CYP1A21C和CYP1A21F基因多态性对健康受试者中奥美拉唑诱导CYP1A2活性的影响。

方法

采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法鉴定CYP2C19和CYP1A2的突变。给予12名CYP2C19的广泛代谢者（EM）（其中6名CYP1A21F/CYP1A21F和6名CYP1A21C/CYP1A21F的CYP1A2）每日120 mg奥美拉唑，持续7天。在口服200 mg咖啡因6小时后，分别于第1天、第9天和第16天三次使用咖啡因血浆指数（副黄嘌呤与咖啡因浓度之比）测定CYP1A2活性。

结果

第9天，CYP1A21F/CYP1A21F和CYP1A21C/CYP1A21F基因型的咖啡因比率存在显著差异（P = 0.002），但在第1天或第16天无显著差异（P > 0.05）。CYP1A21F/CYP1A21F和CYP1A21C/CYP1A21F基因型从第9天到第1天（48%±20%对19%±20%）以及从第9天到第16天（50%±31%对15%±22%）比率变化存在显著差异（P < 0.05）。

结论

CYP1A21C和CYP1A21F基因多态性影响奥美拉唑在体内对CYP1A2活性的诱导作用。