Han X M, Zhou H H
Pharmacogenetics Research Institute, Basic and Clinical Pharmacology Institute, Hunan Medical University, Changsha 410078, China.
Acta Pharmacol Sin. 2000 Aug;21(8):673-9.
CYP450s form a superfamily involved in the metabolism of many endogenous and exogenous substrates. In this review, the substrates, probe drugs, genetic polymorphisms, and associated cancers of CYP1A1, CYP1A2, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 are summarized.
细胞色素P450酶系构成了一个超家族，参与许多内源性和外源性底物的代谢。在本综述中，总结了细胞色素P450 1A1（CYP1A1）、细胞色素P450 1A2（CYP1A2）、细胞色素P450 2C19（CYP2C19）、细胞色素P450 2D6（CYP2D6）、细胞色素P450 2E1（CYP2E1）和细胞色素P450 3A4（CYP3A4）的底物、探针药物、基因多态性及相关癌症。
