Han X M, Chen X P, Wu Q N, Jiang C H, Zhou H H
Pharmacogenetics Research Institute, Basic and Clinical Pharmacology Institute, Hunan Medical University, Changsha 410078, China.
Acta Pharmacol Sin. 2000 Nov;21(11):1031-4.
To observe the G-2964A and C734A genetic polymorphisms of human CYP1A2 in Chinese population.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed in genotyping analysis.
The allele frequencies of A-2964 were 0.25 and 0.22 in Qidong and Changsha populations, respectively. The incidences of A734 were 0.68 in Qidong population and 0.66 in Changsha population. No more than two low-inducibility/activity alleles were presented in one person.
The distribution of the G-2964A and C734A genetic polymorphisms did not show significant difference between Chinese and Japanese populations. The incidence of C734A in Chinese was also similar to that in Caucasian population.
