Kinzler Wendy L, Ananth Cande V, Smulian John C, Vintzileos Anthony M
Department of Obstetrics, Gynecology and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School/Saint Peter's University Hospital, New Brunswick, NJ 08903-0591, USA.
Paediatr Perinat Epidemiol. 2002 Oct;16(4):320-7. doi: 10.1046/j.1365-3016.2002.00449.x.
This study was undertaken to examine the relationship between paternal and maternal age differences and adverse perinatal outcomes in the United States. Data were obtained on singleton pregnancies delivering at >or=20 weeks gestation in the United States in 1995-97 from the National Center for Health Statistics data sets. Adverse perinatal outcomes that were evaluated included fetal death rate (>or=20 weeks), preterm delivery <37 weeks and small-for-gestational-age (SGA) births (birthweight <10th centile for gestational age and corrected for sex). Age difference was defined as paternal minus maternal age. The analysis included 8995274 pregnancies (11.3% blacks, 88.7% whites). An increase in fetal death rate, preterm delivery and SGA births was noted among white women who were older than their male partners. For black mothers older than their partners, there was an increase in fetal death rate when the women were <20 years old, but a decrease in fetal death rate when >35 years old. Neither rates of preterm delivery nor SGA births were increased much for black women with varying parental age differences. This demonstrates that race and maternal age both contribute to the effects of parental age difference on adverse perinatal outcomes.
本研究旨在探讨美国父母年龄差异与不良围产期结局之间的关系。数据取自1995 - 1997年美国国家卫生统计中心数据集中妊娠≥20周的单胎妊娠。评估的不良围产期结局包括胎儿死亡率（≥20周）、孕周<37周的早产以及小于胎龄儿（SGA）出生（出生体重低于同孕周第10百分位数且按性别校正）。年龄差异定义为父亲年龄减去母亲年龄。分析纳入了8995274例妊娠（11.3%为黑人，88.7%为白人）。在年龄比男性伴侣大的白人女性中，胎儿死亡率、早产率和小于胎龄儿出生率均有所上升。对于年龄比伴侣大的黑人母亲，年龄<20岁时胎儿死亡率上升，但年龄>35岁时胎儿死亡率下降。父母年龄差异不同的黑人女性，早产率和小于胎龄儿出生率均无明显升高。这表明种族和母亲年龄均对父母年龄差异对不良围产期结局的影响有作用。
