Auersperg N, Ota T, Mitchell G W E
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.
Int J Gynecol Cancer. 2002 Nov-Dec;12(6):691-703. doi: 10.1046/j.1525-1438.2002.01152.x.
The etiology and early events in the progression of epithelial ovarian carcinomas are among the least understood of all major human malignancies. There are no adequate means for early detection of these neoplasms and, as a result, they are usually diagnosed in late stages. The purpose of this review is to point out some of the peculiar problems and limitations that have hampered progress in ovarian carcinogenesis research and to summarize new approaches and recent advances in our understanding of this process. The review first presents an overview of the properties of the ovarian surface epithelium (OSE) which is thought to be the source of epithelial ovarian carcinomas, followed by a discussion of recent research based on human OSE. This includes sections on methodology for the attainment and study of OSE, investigations of OSE from women with predisposing mutations, and attempts to convert normal OSE to malignancy. This overview is followed by a discussion of the contributions, potential, and limitations of animal models. The knowledge gained by these approaches will likely lead to improvements in our ability to prevent, diagnose, and treat ovarian cancer.
上皮性卵巢癌的病因及进展早期事件是所有主要人类恶性肿瘤中了解最少的。目前尚无足够手段对这些肿瘤进行早期检测，因此，它们通常在晚期才被诊断出来。本综述的目的是指出一些阻碍卵巢癌发生研究进展的特殊问题和局限性，并总结我们对这一过程理解的新方法和最新进展。综述首先概述了被认为是上皮性卵巢癌来源的卵巢表面上皮（OSE）的特性，随后讨论了基于人类OSE的最新研究。这包括获取和研究OSE的方法、对具有易感突变女性的OSE进行的研究，以及将正常OSE转化为恶性肿瘤的尝试。在此概述之后，讨论了动物模型的贡献、潜力和局限性。通过这些方法获得的知识可能会提高我们预防、诊断和治疗卵巢癌的能力。
