卵巢癌的早期浸润前病变

Chene Gautier, Lamblin Gery, Le Bail-Carval Karine, Chabert Philippe, Bakrin Naoual, Mellier Georges

Department of Gynecology, Hôpital Femme Mère Enfant (HFME), University Hospital Lyon, 69000 Lyon, France.

Biomed Res Int. 2014;2014:639252. doi: 10.1155/2014/639252. Epub 2014 Apr 8.

Faced with the catastrophic prognosis for ovarian cancer due to the fact that it is most often diagnosed late at the peritoneal carcinomatosis stage, screening and early detection could probably reduce the mortality rate. A better understanding of the molecular characteristics of the different ovarian cancer subtypes and their specific molecular signatures is indispensable prior to development of new screening strategies. We discuss here the early natural history of ovarian cancer and its origins.

由于卵巢癌大多在腹膜癌病期被诊断出来时已处于晚期，面临着灾难性的预后，筛查和早期检测或许能够降低死亡率。在开发新的筛查策略之前，深入了解不同卵巢癌亚型的分子特征及其特定分子标记是必不可少的。我们在此讨论卵巢癌的早期自然史及其起源。