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Cholesterol homeostasis: not until the SCAP lady INSIGs.

作者信息

Loewen Christopher J R, Levine Timothy P

机构信息

Division of Cell Biology, Institute of Ophthalmology, University College London, EC1V 9EL, London, UK.

出版信息

Curr Biol. 2002 Nov 19;12(22):R779-81. doi: 10.1016/s0960-9822(02)01292-7.

DOI:10.1016/s0960-9822(02)01292-7
PMID:12445404
Abstract

Three new studies have wide implications for cholesterol homeostasis, identifying a novel mechanism by which a sterol-sensing domain functions in the regulated activation of sterol regulatory element binding proteins.

摘要

相似文献

1
Cholesterol homeostasis: not until the SCAP lady INSIGs.
Curr Biol. 2002 Nov 19;12(22):R779-81. doi: 10.1016/s0960-9822(02)01292-7.
2
Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs.胆固醇和25-羟基胆固醇通过不同机制抑制固醇调节元件结合蛋白（SREBPs）的激活，这两种机制均涉及SREBP裂解激活蛋白（SCAP）和胰岛素诱导基因蛋白（Insigs）。
J Biol Chem. 2004 Dec 10;279(50):52772-80. doi: 10.1074/jbc.M410302200. Epub 2004 Sep 27.
3
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.胆固醇稳态的关键步骤：固醇促进SCAP与INSIG-1结合，INSIG-1是一种膜蛋白，有助于将SREBPs保留在内质网中。
Cell. 2002 Aug 23;110(4):489-500. doi: 10.1016/s0092-8674(02)00872-3.
4
CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin.构建无SCAP的肝脏可使固醇调节元件结合蛋白固定在内质网膜上，并防止因低胆固醇和高胰岛素而导致脂质合成增加。
Genes Dev. 2001 Aug 1;15(15):1873-8. doi: 10.1101/gad.916601.
5
[SCAP: a polytopic membrane protein that modulates the sterol regulated cleavage of SREBPs].[SCAP：一种调节固醇调节元件结合蛋白（SREBPs）固醇调节性裂解的多拓扑膜蛋白]
Nihon Rinsho. 2001 Feb;59 Suppl 2:270-6.
6
[SREBP controls cholesterol homeostasis].
Seikagaku. 2004 Jun;76(6):503-8.
7
A closer look at the cholesterol sensor.深入了解胆固醇传感器。
Trends Biochem Sci. 2002 Dec;27(12):596-9. doi: 10.1016/s0968-0004(02)02224-7.
8
Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins.Rho-ROCK-LIMK-丝切蛋白通路调节甾醇调节元件结合蛋白的剪切应力激活。
Circ Res. 2003 Jun 27;92(12):1296-304. doi: 10.1161/01.RES.0000078780.65824.8B. Epub 2003 May 29.
9
Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.SCAP固醇感应结构域中的三个突变阻断了与Insig的相互作用，并使SREBP裂解对固醇不敏感。
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16672-7. doi: 10.1073/pnas.262669399. Epub 2002 Dec 13.
10
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.胆固醇剥夺和胰岛素升高诱导的肝脏脂质合成增加需要固醇调节元件结合蛋白裂解激活蛋白（SCAP）。
Genes Dev. 2001 May 15;15(10):1206-16. doi: 10.1101/gad.891301.

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矿物质和蛋白质含量低且添加了n-3脂肪酸和共轭亚油酸的日粮对青年公牛肝脏转录组的影响
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BMC Mol Biol. 2009 Feb 23;10:13. doi: 10.1186/1471-2199-10-13.
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Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.Insig通过控制裂殖酵母中的酶磷酸化来调节HMG-CoA还原酶。
Cell Metab. 2008 Dec;8(6):522-31. doi: 10.1016/j.cmet.2008.09.004.
6
Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.在裂殖酵母Scap中鉴定出二十三种组成型激活固醇调节元件结合蛋白（SREBP）的突变。
J Lipid Res. 2008 Sep;49(9):2001-12. doi: 10.1194/jlr.M800207-JLR200. Epub 2008 May 23.
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4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress.4-甲基甾醇在低氧和细胞应激条件下调节裂殖酵母中的SREBP-Scap。
J Biol Chem. 2007 Aug 17;282(33):24388-96. doi: 10.1074/jbc.M701326200. Epub 2007 Jun 26.
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Cloning, comparative characterization of porcine SCAP gene, and identification of its two splice variants.猪SCAP基因的克隆、比较特征分析及其两种剪接变体的鉴定。
Mol Genet Genomics. 2006 Aug;276(2):187-96. doi: 10.1007/s00438-006-0134-8. Epub 2006 May 17.