Leaver H A, Wharton S B, Bell H S, Leaver-Yap I M M, Whittle I R
Department of Clinical Neurosciences, University of Edinburgh, UK.
Prostaglandins Leukot Essent Fatty Acids. 2002 Nov;67(5):283-92. doi: 10.1054/plef.2002.0431.
Highly unsaturated fatty acids (HUFAs) are naturally occurring anti-tumour agents. HUFAs act as intracellular signalling molecules in cell proliferation and death. In human glioma, HUFAs may stimulate tumour regression and apoptosis. An implantation glioma model, using the C6 glioma cell line, was used to investigate the bioactivity of locally infused n-6 HUFA gamma linolenic acid (GLA). Rat brains (15 normal and 37 C6 tumour bearing) were infused with vehicle or GLA 200 microM-2 mM. The most active local concentration of GLA for anti-tumour activity was 2 mM, infused at 1 microl/h over 7 days. Tumour regression, increased apoptosis and decreased proliferation were observed in tumours of rats infused with this concentration of GLA. Little effect on normal neuronal tissue was detected. The intraparenchymal route was an effective method of GLA administration in the treatment of glioma. These studies provide further insights into the potential role of HUFAs as anti-glioma agents.
高度不饱和脂肪酸（HUFAs）是天然存在的抗肿瘤剂。HUFAs在细胞增殖和死亡中作为细胞内信号分子发挥作用。在人类胶质瘤中，HUFAs可能刺激肿瘤消退和凋亡。使用C6胶质瘤细胞系的植入性胶质瘤模型来研究局部注入的n-6 HUFAγ-亚麻酸（GLA）的生物活性。给大鼠脑（15只正常大鼠和37只携带C6肿瘤的大鼠）注入赋形剂或200微摩尔/升至2毫摩尔的GLA。对肿瘤活性最有效的GLA局部浓度为2毫摩尔，以1微升/小时的速度注入7天。在注入该浓度GLA的大鼠肿瘤中观察到肿瘤消退、凋亡增加和增殖减少。未检测到对正常神经组织有明显影响。实质内途径是GLA给药治疗胶质瘤的有效方法。这些研究进一步深入了解了HUFAs作为抗胶质瘤剂的潜在作用。
