Laurà M, Gregson N A, Curmi Y, Hughes R A C
Department of Neurological Sciences, Psychiatry and Anaesthesiology, University of Messina, 98125, Messina, Italy.
J Neuroimmunol. 2002 Dec;133(1-2):56-9. doi: 10.1016/s0165-5728(02)00359-4.
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that exerts neurotrophic and myotrophic actions. We have investigated the effect of LIF in experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome (GBS). Treatment with LIF at the onset of the disease showed a slight, but not significant, improvement in the clinical course but no effect on nerve histology.
白血病抑制因子（LIF）是一种具有多效性的细胞因子，发挥着神经营养和肌营养作用。我们研究了LIF在实验性自身免疫性神经炎（EAN）中的作用，EAN是格林-巴利综合征（GBS）的一种动物模型。在疾病发作时用LIF治疗，临床病程有轻微改善，但不显著，且对神经组织学无影响。
