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果蝇中含ZAD的C2H2锌指基因的基因组扩增与聚类

Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila.

作者信息

Chung Ho-Ryun, Schäfer Ulrich, Jäckle Herbert, Böhm Siegfried

机构信息

Abteilung Molekulare Entwicklungsbiologie, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg, D-37077 Göttingen, Germany.

出版信息

EMBO Rep. 2002 Dec;3(12):1158-62. doi: 10.1093/embo-reports/kvf243. Epub 2002 Nov 21.

DOI:10.1093/embo-reports/kvf243
PMID:12446571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1308319/
Abstract

C2H2 zinc-finger proteins (ZFPs) constitute the largest family of nucleic acid binding factors in higher eukaryotes. In silico analysis identified a total of 326 putative ZFP genes in the Drosophila genome, corresponding to approximately 2.3% of the annotated genes. Approximately 29% of the Drosophila ZFPs are evolutionary conserved in humans and/or Caenorhabditis elegans. In addition, approximately 28% of the ZFPs contain an N-terminal zinc-finger-associated C4DM domain (ZAD) consisting of approximately 75 amino acid residues. The ZAD is restricted to ZFPs of dipteran and closely related insects. The evolutionary restriction, an expansion of ZAD-containing ZFP genes in the Drosophila genome and their clustering at few chromosomal sites are features reminiscent of vertebrate KRAB-ZFPs. ZADs are likely to represent protein-protein interaction domains. We propose that ZAD-containing ZFP genes participate in transcriptional regulation either directly or through site-specific modification and/or regulation of chromatin.

摘要

C2H2型锌指蛋白（ZFPs）是高等真核生物中最大的核酸结合因子家族。通过计算机分析在果蝇基因组中总共鉴定出326个假定的ZFP基因，约占注释基因的2.3%。约29%的果蝇ZFP在人类和/或秀丽隐杆线虫中具有进化保守性。此外，约28%的ZFP含有一个由约75个氨基酸残基组成的N端锌指相关C4DM结构域（ZAD）。ZAD仅限于双翅目昆虫及亲缘关系较近昆虫的ZFP。这种进化限制、果蝇基因组中含ZAD的ZFP基因的扩增以及它们在少数染色体位点的聚集，是类似于脊椎动物KRAB-ZFP的特征。ZAD可能代表蛋白质-蛋白质相互作用结构域。我们提出，含ZAD的ZFP基因直接或通过染色质的位点特异性修饰和/或调控参与转录调控。