纤维化肺泡炎实验模型的病理学与生物化学检查对比
Comparison between pathological and biochemical investigations on an experimental model of fibrosing alveolitis.
作者信息
von Wichert P, Morgenroth K
出版信息
Respiration. 1976;33(1):36-46. doi: 10.1159/000193686.
Subcutaneously injected Freund's adjuvant caused a fibrosing alveolitis in guinea pigs. This model served to compare biochemical and morphological parameters. The phospholipids were quantitatively extracted from lung tissue, separated and estimated. The fatty acid composition of lecithin was analysed. We observed a correlation between the histologic alterations and the content of phospholipids. A constantly higher phospholipid content was measured in the affected lungs in comparison to the normal ones; however, the composition of the phospholipids changed. The close correlation between the course of the inflammation and the biochemical pattern seems to indicate a function-correlated control of lung metabolism.
皮下注射弗氏佐剂可导致豚鼠发生纤维化肺泡炎。该模型用于比较生化和形态学参数。从肺组织中定量提取、分离并测定磷脂。分析了卵磷脂的脂肪酸组成。我们观察到组织学改变与磷脂含量之间存在相关性。与正常肺相比，在受影响的肺中测得的磷脂含量持续较高；然而，磷脂的组成发生了变化。炎症过程与生化模式之间的密切相关性似乎表明肺代谢存在与功能相关的调控。
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