Krause W, Muschick P, Krüger U
Research Laboratories of Schering AG, Berlin, Germany.
Invest Radiol. 2002 Dec;37(12):698-705. doi: 10.1097/00004424-200212000-00010.
Use of near-infrared reflection spectroscopy (NIR-RS) as a new model to assess renal tolerance of contrast agents and determination of the effects of a prostacyclin analogue and of two phosphodiesterase inhibitors on renal tolerance.
NIR-RS was used to measure total hemoglobin, oxygenated hemoglobin and tissue oxygen saturation in the renal cortex of rats and the effect of diatrizoate, iopromide and iotrolan injected at 1 g iodine/kg alone or together with the prostacyclin derivative, iloprost, or the phosphodiesterase inhibitors, rolipram and mesopram, on these parameters.
Injection of the contrast media alone resulted in a 10% to 35% depression of total hemoglobin, oxygenated hemoglobin, and tissue oxygen saturation approximately 40 to 100 seconds after administration, whereas saline showed no effect and mannitol solution only a minor effect. Coadministration of iloprost or pretreatment with the phosphodiesterase inhibitors, rolipram or mesopram, significantly attenuated the contrast media-induced effects.
NIR-RS might be useful for the determination of contrast media-induced side effects. Stable prostacyclin analogues or phosphodiesterase inhibitors have the potential to mitigate these side effects.
使用近红外反射光谱法（NIR-RS）作为一种新模型来评估造影剂的肾耐受性，并确定前列环素类似物和两种磷酸二酯酶抑制剂对肾耐受性的影响。
使用NIR-RS测量大鼠肾皮质中的总血红蛋白、氧合血红蛋白和组织氧饱和度，以及单独以1 g碘/千克注射泛影酸盐、碘普罗胺和碘曲仑，或与前列环素衍生物伊洛前列素，或磷酸二酯酶抑制剂咯利普兰和甲磺酸丙酯一起注射对这些参数的影响。
单独注射造影剂在给药后约40至100秒导致总血红蛋白、氧合血红蛋白和组织氧饱和度降低10%至35%，而生理盐水无影响，甘露醇溶液仅有轻微影响。伊洛前列素联合给药或用磷酸二酯酶抑制剂咯利普兰或甲磺酸丙酯预处理可显著减轻造影剂诱导的影响。
NIR-RS可能有助于确定造影剂引起的副作用。稳定的前列环素类似物或磷酸二酯酶抑制剂有可能减轻这些副作用。
