Mankarious Leila A, Cherukupally Shilpa R, Adams Allison B
Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA.
Otolaryngol Head Neck Surg. 2002 Nov;127(5):442-7. doi: 10.1067/mhn.2002.128895.
Our goal was to determine the effects of both perichondrial and intracartilaginous injury in the developing rabbit subglottis versus normal development.
We conducted a descriptive, pilot study of changes in the shape and histology of the subglottis after a controlled depth of injury in 27 New Zealand White rabbits, ages 4 weeks, 8 weeks, and 1(1/2) years.
Within each age group, 3 animals underwent no surgery, 3 underwent perichondrial injury, and 3 underwent intracartilaginous injury.
Perichondrially injured animals in the 4-week age group developed a marked abnormality in the shape of the cricoid cartilage in the injured region. Cartilage of the perichondriallly injured animals in the 8-week and 1(1/2)-year groups became histologically consistent with fibrous tissue. The cartilage of all animals that underwent intracartilaginous injury was replaced with fibrous tissue.
In this observational study, we identified 3 relevant findings. First, the responses of the cartilage to a perichondrial injury suggest that the luminal soft tissues may exert some morphologic control in developmentally young animals. Second, only the 4-week-old group's cartilage was tolerant of a perichondrial injury with continued growth of the ring. Third, no animal's cartilage could withstand an intracartilaginous injury regardless of age.
我们的目标是确定在发育中的兔声门下区，软骨膜损伤和软骨内损伤与正常发育相比所产生的影响。
我们对27只4周龄、8周龄和1.5岁的新西兰白兔进行了一项描述性的初步研究，在控制损伤深度后观察声门下区的形状和组织学变化。
在每个年龄组中，3只动物未接受手术，3只接受软骨膜损伤，3只接受软骨内损伤。
4周龄组中接受软骨膜损伤的动物在损伤区域的环状软骨形状出现明显异常。8周龄和1.5岁组中接受软骨膜损伤的动物的软骨在组织学上变得与纤维组织一致。所有接受软骨内损伤的动物的软骨都被纤维组织所取代。
在这项观察性研究中，我们发现了3个相关结果。第一，软骨对软骨膜损伤的反应表明，管腔内软组织可能在发育中的幼小动物中发挥一些形态学控制作用。第二，只有4周龄组的软骨能够耐受软骨膜损伤，环状软骨能继续生长。第三，无论年龄大小，没有动物的软骨能够承受软骨内损伤。
