Anderson I L, Jones E W
Anesthesiology. 1976 Jan;44(1):57-61.
Halothane-induced contractures in isolated muscle fibers from swine susceptible to malignant hyperthermia (MHS) were significantly less when fibers were incubated in KRB plus 6.2 x 10(-6) M dantrolene sodium prior to the administration of 4 per cent halothane. Administration of dantrolene sodium at the time of maximum contraction to NHS fibers in which contractures had been induced by halothane significantly increased the rate of relaxation of these fibers compared with similar fibers not treated with dantrolene sodium. This study indicates possible prophylactic and therapeutic value of dantrolene sodium in malignant hyperthermia and suggests that the previously reported effectiveness of dantrolene sodium in preventing and treating halothane-induced contractures may be due, at least in part, to its direct effect on muscles.
在给予4%氟烷之前，将猪恶性高热（MHS）易感猪的离体肌纤维在含6.2×10⁻⁶ M丹曲林钠的KRB中孵育，氟烷诱导的挛缩明显减少。在氟烷诱导挛缩的NHS纤维最大收缩时给予丹曲林钠，与未用丹曲林钠处理的类似纤维相比，这些纤维的松弛速率显著增加。本研究表明丹曲林钠在恶性高热中可能具有预防和治疗价值，并提示先前报道的丹曲林钠预防和治疗氟烷诱导挛缩的有效性可能至少部分归因于其对肌肉的直接作用。
