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硫氰酸钠与丹曲林钠对哺乳动物离体骨骼肌作用的比较。

A comparison of the effects of sodium thiocyanate and dantrolene sodium on a mammalian isolated skeletal muscle.

作者信息

Moulds R F

出版信息

Br J Pharmacol. 1977 Jan;59(1):129-33. doi: 10.1111/j.1476-5381.1977.tb06986.x.

DOI:10.1111/j.1476-5381.1977.tb06986.x
PMID:836993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1667722/
Abstract

1 A combination of electrical and pharmacological stimulation has been used to compare the effects of sodium thiocyanate and dantrolene sodium on the excitation-contraction coupling (ECC) mechanism of the mouse soleus muscle. 2 Thiocyanate prolonged the 'active state' after electrical stimulation and increased the response to 8 mM caffeine and 80 mM KCl. Dantrolene had an opposite effect to thiocyanate on all the indices studied. 3 It is concluded that the mechanism of action of dantrolene is by inhibition of the release of the calcium ions involved in the ECC mechanism, probably at the level of the transverse tubules.

摘要
  1. 已采用电刺激和药理刺激相结合的方法来比较硫氰酸钠和丹曲林钠对小鼠比目鱼肌兴奋 - 收缩偶联（ECC）机制的影响。2. 硫氰酸盐延长了电刺激后的“活性状态”，并增强了对8 mM咖啡因和80 mM氯化钾的反应。丹曲林在所研究的所有指标上对硫氰酸盐有相反的作用。3. 得出的结论是，丹曲林的作用机制是抑制参与ECC机制的钙离子释放，可能是在横管水平。

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引用本文的文献

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2
The failing ventilatory pump.功能衰竭的通气泵
Lung. 1982;160(2):59-84. doi: 10.1007/BF02719275.
3
Dantrolene--in vitro studies in malignant hyperthermia susceptible (MHS) and normal skeletal muscle.丹曲林——对恶性高热易感（MHS）和正常骨骼肌的体外研究。
Can Anaesth Soc J. 1984 Mar;31(2):130-54. doi: 10.1007/BF03015252.
4
Dantrolene.丹曲林
Can Anaesth Soc J. 1984 Jan;31(1):61-75. doi: 10.1007/BF03011484.
5
The effects of glycerol detubulation, of manganese ions, of dantrolene and of nitrate ions on the responses of isolated chronically denervated soleus muscles of the mouse to acetylcholine.甘油去管化、锰离子、丹曲林和硝酸根离子对小鼠慢性去神经支配比目鱼肌分离标本对乙酰胆碱反应的影响。
Br J Pharmacol. 1978 Jan;62(1):107-13. doi: 10.1111/j.1476-5381.1978.tb07012.x.
6
Is malignant hyperpyrexia muscle denervated?恶性高热时肌肉是否去神经支配？
J Neurol Neurosurg Psychiatry. 1977 Oct;40(10):975-8. doi: 10.1136/jnnp.40.10.975.

本文引用的文献

1
1-[(5-arylfurfurylidene)amino]hydantoins. A new class of muscle relaxants.1-[(5-芳基糠叉基)氨基]乙内酰脲。一类新型肌肉松弛剂。
J Med Chem. 1967 Sep;10(5):807-10. doi: 10.1021/jm00317a011.
2
Potentiating effect of potassium on skeletal muscle twitch.钾对骨骼肌抽搐的增强作用。
Am J Physiol. 1969 Sep;217(3):898-902. doi: 10.1152/ajplegacy.1969.217.3.898.
3
The relationship between caffeine contracture of intact muscle and the effect of caffeine on reticulum.完整肌肉的咖啡因挛缩与咖啡因对肌浆网的作用之间的关系
J Gen Physiol. 1968 Nov;52(5):750-9. doi: 10.1085/jgp.52.5.750.
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Excitation-contraction coupling in skeletal muscle.骨骼肌中的兴奋-收缩偶联
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Pharmacological actions on excitation-contraction coupling in striated muscle.对横纹肌兴奋-收缩偶联的药理作用。
Fed Proc. 1968 Jan-Feb;27(1):126-31.
6
Biochemical basis of malignant hyperpyrexia.恶性高热的生化基础。
Br Med J. 1974 May 4;2(5913):241-4. doi: 10.1136/bmj.2.5913.241.
7
Effect of dantrolene sodium on calcium movements in single muscle fibres.丹曲林钠对单根肌纤维钙转运的影响。
Nature. 1974 Dec 20;252(5485):728-30. doi: 10.1038/252728a0.
8
Site of action of dantrolene in frog sartorius muscle.丹曲林在青蛙缝匠肌中的作用部位。
J Pharmacol Exp Ther. 1974 Apr;189(1):202-12.
9
Studies on the mechanism of action of dantrolene sodium. A skeletal muscle relaxant.丹曲林钠作用机制的研究。一种骨骼肌松弛剂。
Naunyn Schmiedebergs Arch Pharmacol. 1972;275(1):83-94. doi: 10.1007/BF00505069.
10
Augmentation of caffeine-contracture tension by twitch-potentiating agents in frog toe muscle.
Can J Physiol Pharmacol. 1971 Oct;49(10):889-900. doi: 10.1139/y71-124.