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[与抽动相关的共病障碍]

[Comorbid disorders associated with tics].

作者信息

Fernández-Alvarez E

机构信息

Servicio de Neuropediatría, Hospital Sant Joan de Déu, Unidad Integrada de Pediatría, Universidad de Barcelona, Barcelona, Spain.

出版信息

Rev Neurol. 2002 Feb;34 Suppl 1:S122-9.

Abstract

INTRODUCTION

Tics are the most frequent abnormal movements in children. This is one reason for their importance. Another reason is their relationship to fascinating disturbances of human behaviour such as compulsion and obsessions. Several 'behavioural disorders', mainly attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), are more frequent in patients with tics than in the general population. These associated disorders (named 'comorbid') are probably of more consequence than the tics. Relationship between tics and comorbid disorders is not well known. This review considers data, consequences, hypothesis and management of comorbid disorders associated to tics.

DEVELOPMENT

From the personal series of children with tics, data of comorbid disorders associated to tics was analysed. Of 340 cases of tics, 132 (39%) cases have ADHD, 135 (40%) cases have OCD, obsessive compulsive symptoms (OCS) or obsessive-compulsive behaviour (OCB). 68 (20%) cases have both ADHD and OCD. Considering only Tourette cases (219) the figures are only slight higher: ADHD (42%), OCD (45%) and ADHD plus OCD (24%) suggesting that all the spectrum of tics has a common basis.

CONCLUSIONS

Familial studies shows that 44 percent of the patients with tics have a positive familial history of tics and 30 percent positive familial history of obsessive compulsive signs. The data of the literature on the tics and comorbid disorders relationship is also revised.

摘要

引言

抽动是儿童中最常见的异常运动。这是其重要性的原因之一。另一个原因是它们与诸如强迫和痴迷等引人入胜的人类行为障碍有关。几种“行为障碍”,主要是注意力缺陷多动障碍(ADHD)和强迫症(OCD),在抽动患者中比在普通人群中更常见。这些相关障碍(称为“共病”)可能比抽动更具后果性。抽动与共病障碍之间的关系尚不清楚。本综述考虑了与抽动相关的共病障碍的数据、后果、假说和管理。

发展

从个人的抽动儿童系列中,分析了与抽动相关的共病障碍的数据。在340例抽动病例中,132例(39%)患有ADHD,135例(40%)患有OCD、强迫症状(OCS)或强迫行为(OCB)。68例(20%)同时患有ADHD和OCD。仅考虑图雷特氏病例(219例),这些数字仅略高:ADHD(42%)、OCD(45%)和ADHD加OCD(24%),表明所有抽动谱系都有一个共同基础。

结论

家族研究表明,44%的抽动患者有抽动的阳性家族史,30%有强迫体征的阳性家族史。关于抽动与共病障碍关系的文献数据也进行了修订。

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