Singal D P, Younglai E V, Naipaul N
Tissue Antigens. 1975 Feb;5(1):19-25. doi: 10.1111/j.1399-0039.1975.tb00521.x.
Plasma samples from 28 renal allograft recipients were studied for the presence of alloantibodies blocking MLC response. MLC blocking antibodies were found in plasma samples obtained from 19 recipients, six with rejected allograft and 13 with long-term surviving transplant. In many instances, these antibodies were found in the absence of detectable lymphocytotoxic antibodies. The MLC blocking activity resides in IgG fractions of plasma samples and was decreased only after absorption with lymphocytes, no effect on blocking was observed by absorption with platelets and fibroblasts.
对28例肾移植受者的血浆样本进行研究，以检测是否存在阻断混合淋巴细胞反应（MLC）的同种抗体。在19例受者的血浆样本中发现了MLC阻断抗体，其中6例移植肾已被排斥，13例移植肾长期存活。在许多情况下，这些抗体在未检测到淋巴细胞毒性抗体时就已存在。MLC阻断活性存在于血浆样本的IgG组分中，仅在用淋巴细胞吸收后活性降低，而用血小板和成纤维细胞吸收则未观察到对阻断作用的影响。
