Kurita Akira, Nagayoshi Hirokazu, Okamoto Yasuhiro, Takase Bonpei, Ishizuka Toshiaki, Oiwa Hiromichi
National Defense Medical College, Division of Biomedical Engineering, Tokorozawa, Saitama, Japan.
Mil Med. 2002 Nov;167(11):934-8.
Autonomic nerve functions under severe hyperbaric pressure were evaluated by measuring heart rate variability (HRV) and catecholamine excretion rate in 16 normal volunteers in submarine experimental facilities simulating conditions 330 m below sea level. HRV and urinary catecholamine levels were evaluated to assess sympathetic and parasympathetic tone. High-frequency HRV increased from 5.6 +/- 1.3 to 6.3 +/- 1.4 ms2 (p < 0.05), and SD of the average normal R to R intervals for 5-minute index (SDNNI) (time domain HRV parameter) increased from 77.2 +/- 32.7 to 93 +/- 33.8 ms (p < 0.05) after 3 days. Adrenaline/creatinine increased by 18% from a basal value of 4.04 +/- 0.44 ng/dL/h. Also, there was significant negative correlation between high-frequency and urinary cathecholamine levels. Evaluation of autonomic nerve functions under hyperbaric conditions by measuring HRV was shown to be a useful method. Thus, the present results indicate that the autonomic nerve functions of people who work under deep-sea conditions can be evaluated adequately by measuring HRV.
在模拟海平面以下330米条件的潜艇实验设施中，通过测量16名正常志愿者的心率变异性（HRV）和儿茶酚胺排泄率，对严重高压下的自主神经功能进行了评估。通过评估HRV和尿儿茶酚胺水平来评估交感神经和副交感神经张力。高频HRV从5.6±1.3增加到6.3±1.4毫秒²（p<0.05），5分钟指数的平均正常R到R间期标准差（SDNNI）（时域HRV参数）在3天后从77.2±32.7增加到93±33.8毫秒（p<0.05）。肾上腺素/肌酐从基础值4.04±0.44纳克/分升/小时增加了18%。此外，高频与尿儿茶酚胺水平之间存在显著负相关。结果表明，通过测量HRV评估高压条件下的自主神经功能是一种有用的方法。因此，目前的结果表明，通过测量HRV可以充分评估在深海条件下工作的人的自主神经功能。
