Boltri John M, Gordon Elizabeth R, Vogel Robert L
Family Health Center, Medical Center of Central Georgia, Macon 31206-3608, USA.
Fam Med. 2002 Nov-Dec;34(10):729-31.
This study evaluated the effect of pharmaceutical samples on the prescribing habits of family practice residents and faculty in the treatment of hypertension.
Charts from two time periods were reviewed for a diagnosis of hypertension--January and February 1997 when drug samples were available and January and February 1998 when sample distribution was prohibited. Progress notes were assessed for medication prescribed, patient age, and doctor seen. Prescribed antihypertensive medications were defined as first- or second-line drugs based on the Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI). Comparisons were made between the two time periods and between faculty and residents.
Overall, faculty were much less likely than residents to prescribe first-line medications: 43% versus 57%. Following prohibition of sample distribution, there was an increase in first-line antihypertensive use from 38% to 61%.
The prescription of first-line drugs for the treatment of hypertension increased after drug sample distribution was prohibited. Studies are needed to determine the extent to which drug sample availability affects prescription practices.
本研究评估了药品样品对家庭医疗住院医师和教员治疗高血压时处方习惯的影响。
回顾两个时间段的病历以诊断高血压——1997年1月和2月有药品样品时，以及1998年1月和2月禁止样品发放时。评估病程记录中所开药物、患者年龄和看诊医生。根据美国国家联合委员会关于预防、检测、评估和治疗高血压的第六次报告（JNC VI），将所开的抗高血压药物定义为一线或二线药物。对两个时间段之间以及教员和住院医师之间进行了比较。
总体而言，教员比住院医师开具一线药物的可能性要小得多：分别为43%和57%。禁止样品发放后，一线抗高血压药物的使用从38%增加到61%。
禁止发放药品样品后，用于治疗高血压的一线药物处方增加。需要开展研究以确定药品样品的可得性对处方行为的影响程度。
