a Grant Medical College and Sir JJ Group of Hospitals , Mumbai , India.
Clin Exp Hypertens. 2018;40(2):150-154. doi: 10.1080/10641963.2017.1346112. Epub 2017 Aug 17.
Hypertension is one of the leading risk factors for cardiovascular, cerebrovascular, and renal disease. Its increasing prevalence and treatment costs influence the prescribing pattern among physicians. Drug utilization studies provide insights into the current prescribing practices and help us facilitate the rational use of drugs. We carried out the present study to assess the pattern of drug utilization in hypertensive patients.
Adults seeking treatment for hypertension were recruited. Prescriptions were studied for demographic and drug-use details. The World Health Organization indices for drug utilization were evaluated. The percentage of prescriptions adhering to the recent guidelines was determined.
Enalapril was the most commonly prescribed drug. Monotherapy was used in 71.8% of the cases. However, 42% of the cases were newly diagnosed. The ratio of prescribed daily dose and defined daily dose showed underutilization of enalapril and atenolol and overutilization of amlodipine. About 87.5% of the prescriptions adhered to Eighth Joint National Committee guidelines. Most of the medications were available at the hospital pharmacy store and were prescribed by their generic names. Total 65.3% of the concomitant medications were not listed in the World Health Organization essential list of medicines. The average number of drugs prescribed was six. A median cost of 14.6 and 94.5 rupees was spent, respectively, on anti-hypertensive and concomitant medications per encounter.
The adherence to the guideline was good. Polypharmacy can be reduced by avoiding the prescription of unnecessary medications and promoting the use of fixed-dose combinations.
高血压是心血管、脑血管和肾脏疾病的主要危险因素之一。其患病率的增加和治疗费用的增加影响了医生的处方模式。药物利用研究提供了当前处方实践的见解，并有助于我们促进药物的合理使用。我们进行了本项研究，以评估高血压患者的药物利用模式。
招募寻求高血压治疗的成年人。研究处方的人口统计学和药物使用详细信息。评估世界卫生组织药物利用指数。确定符合最新指南的处方比例。
依那普利是最常用的药物。在 71.8%的病例中使用了单药治疗。然而，42%的病例是新诊断的。处方日剂量与限定日剂量的比值表明依那普利和阿替洛尔的利用率不足，氨氯地平的利用率过高。约 87.5%的处方符合第八届联合国家委员会指南。大多数药物可在医院药房购买，并以其通用名开处方。总共 65.3%的伴随药物未列入世界卫生组织基本药物清单。处方的平均药物数为六种。每次就诊抗高血压药物和伴随药物的中位数费用分别为 14.6 卢比和 94.5 卢比。
对指南的遵循情况良好。通过避免开具不必要的药物并促进固定剂量组合的使用，可以减少多药治疗。
