Mornex Françoise
Département de radiothérapie-oncologie, EA 643, Centre hospitalier Lyon-Sud, Pierre-Bénite, 69310 Lyon.
Bull Cancer. 2002 Aug;89 Spec No:S127-33.
Gemcitabine is a molecule presenting with major radiosensitizing or radio-potentiator capacities. This property has been extensively studied in vitro, with clinical therapeutic implications. Chemotherapy and radiation are very often used together, most of the time concurrently. This review analyses the results obtained with combined gemcitabine and radiation, for non small cell lung cancer, pancreatic adenocarcinoma, head and neck and uterine cervix carcinomas. Several therapeutic schemes are presented, for each tumor location. A description of the toxicities observed is presented, including the recall phenomenon description. Promising results justify the numerous current trials, as well as enthusiasm initiated by this therapeutic association.
吉西他滨是一种具有主要放射增敏或放射增效能力的分子。这一特性已在体外进行了广泛研究，并具有临床治疗意义。化疗和放疗经常联合使用，大多数情况下是同时进行。本综述分析了吉西他滨与放疗联合用于非小细胞肺癌、胰腺腺癌、头颈癌和子宫颈癌的研究结果。针对每个肿瘤部位介绍了几种治疗方案。还介绍了观察到的毒性，包括回忆现象的描述。有前景的结果证明了当前众多试验的合理性，以及这种治疗联合所引发的热情。
