Klastersky J, Awada A
Service de Médecine Interne, Institut Jules Bordet, l'Université Libre de Bruxelles.
Rev Med Brux. 1997 Oct;18(5):328-34.
Gemcitabine, a new nucleotide analogue, is a promising chemotherapeutic agent for pancreatic, lung, ovarian and breast carcinomas. Its low toxicity (mainly hematologic) makes it a good choice for palliative treatment in patients who would otherwise be unable to tolerate aggressive therapy. The combination of gemcitabine with other anticancer agents such as cisplatin and anthracyclines appears to be associated with high response rates. Finally, gemcitabine is a potent radiosensitizing agent and should definitely be tested in combination with radiotherapy mainly in locally advanced disease.
吉西他滨是一种新型核苷酸类似物，是一种有前景的用于治疗胰腺癌、肺癌、卵巢癌和乳腺癌的化疗药物。其低毒性（主要是血液学毒性）使其成为那些无法耐受积极治疗的患者姑息治疗的良好选择。吉西他滨与其他抗癌药物如顺铂和蒽环类药物联合使用似乎与高缓解率相关。最后，吉西他滨是一种有效的放射增敏剂，肯定应主要在局部晚期疾病中与放疗联合进行试验。
