评估70/30聚（L-丙交酯-co-D，L-丙交酯）用作可吸收椎间融合器的性能。
Evaluation of 70/30 poly (L-lactide-co-D,L-lactide) for use as a resorbable interbody fusion cage.
作者信息
Toth Jeffrey M, Estes Bradley T, Wang Mei, Seim Howard B, Scifert Jeffrey L, Turner A Simon, Cornwall G Bryan
机构信息
Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, USA.
出版信息
J Neurosurg. 2002 Nov;97(4 Suppl):423-32. doi: 10.3171/spi.2002.97.4.0423.
OBJECT
Titanium lumbar interbody spinal fusion devices are reported to be 90% effective in cases requiring single-level lumbar interbody arthrodesis, although radiographic determination of fusion has been debated.
METHODS
Using blinded radiographic, biomechanical, histological, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(L-lactide-co-D,L-lactide) interbody fusion device packed with autograft or recombinant human bone morphogenetic protein-2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologically confirmed fusion was demonstrated at 3 months to 24 months postimplantation. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.
CONCLUSIONS
Use of this material in interbody fusion may be a viable alternative to metals.
目的
据报道，钛腰椎椎间融合器在需要单节段腰椎椎间融合的病例中有效率达90%，尽管融合的影像学判定一直存在争议。
方法
本研究的研究人员采用盲法影像学、生物力学、组织学和统计学测量方法，在25只绵羊体内于3、6、12、18和24个月时评估了一种填充有自体移植物或重组人骨形态发生蛋白-2的胶原海绵上的可透射线的70/30聚（L-丙交酯-co-D，L-丙交酯）椎间融合器。在植入后3个月至24个月时，融合刚度增加、影像学融合及组织学证实融合均呈上升趋势。在所有术后处死时间，装置降解均伴有轻度至中度慢性炎症反应。
结论
在椎间融合中使用这种材料可能是金属的一种可行替代方案。
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