Kempin Sanford, Gutierrez Jorge, Wilson Elizabeth, Lowery Colin, Diasio Robert
Comprehensive Cancer Center, 325 West 15 Street, New York, NY 10011, USA.
Cancer Invest. 2002;20(7-8):992-5. doi: 10.1081/cnv-120005915.
Raltitrexed (Tomudex), a classical folate antagonist, is a selective inhibitor of thymidylate synthase (TS). It has significant single-agent activity in metastatic colorectal cancer. Severe life-threatening toxicity related to the administration of 5-fluorouracil and leucovorin is described in two patients, both of whom were not deficient in dihydropyrimidine dehydrogenase. Raltitrexed was administered to both patients with clinically acceptable side effects and allowed a TS inhibitor to be administered as part of an adjuvant program.
雷替曲塞（商品名：拓优得）是一种经典的叶酸拮抗剂，是胸苷酸合成酶（TS）的选择性抑制剂。它在转移性结直肠癌中具有显著的单药活性。两名患者出现了与5-氟尿嘧啶和亚叶酸钙给药相关的严重危及生命的毒性反应，这两名患者均不存在二氢嘧啶脱氢酶缺乏。对这两名患者使用雷替曲塞后副作用在临床可接受范围内，并允许将TS抑制剂作为辅助治疗方案的一部分进行给药。
