雷替曲塞（拓优得）：用于结直肠癌患者及5-氟尿嘧啶相关心脏毒性患者的替代药物。
Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
作者信息
Köhne C H, Thuss-Patience P, Friedrich M, Daniel P T, Kretzschmar A, Benter T, Bauer B, Dietz R, Dörken B
机构信息
Department of Haematology/Oncology and Tumor Immunology Robert-Rössle-Klinik, Virchow-Klinikum, Medizinische Fakultät Charite der Humboldt-Universität zu Berlin, Germany.
出版信息
Br J Cancer. 1998 Mar;77(6):973-7. doi: 10.1038/bjc.1998.160.
Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardiotoxicity. 5-FU cardiotoxicity is not due to the antineoplastic mechanisms via thymidilate synthase.
两名经证实患有5-氟尿嘧啶（5-FU）相关心脏毒性的患者接受了特异性胸苷酸合成酶抑制剂雷替曲塞治疗，且治疗安全，未出现心脏毒性迹象。对于晚期结直肠癌合并5-FU相关心脏毒性的患者，雷替曲塞可能是一种替代药物。5-FU心脏毒性并非由通过胸苷酸合成酶的抗肿瘤机制所致。
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