Bond Alyson J, Wingrove Janet, Valerie Curran H, Lader Malcolm H
Section of Clinical Psychopharmacology, ASB, Institute of Psychiatry, Kings College, De Crespigny Park, SE5 8AF, London, UK.
J Affect Disord. 2002 Dec;72(3):267-71. doi: 10.1016/s0165-0327(01)00469-4.
Very few studies have examined the combination of drug and psychological treatment in generalised anxiety disorder (GAD). Theoretically, buspirone should be a useful drug to combine with a learning-based therapy.
Sixty patients with GAD were randomly assigned to treatment with buspirone or placebo, combined with anxiety management training or non-directive therapy for a period of 8 weeks.
Forty-four patients with a mean Hamilton Anxiety Scale score of 28 completed treatment. There were no significant differences between treatment groups. All groups showed significant improvement after 8 weeks compared to baseline. There were no baseline differences between those who completed the trial and those who did not but patients given buspirone were more likely to drop out.
A short course of psychological therapy, whether or not accompanied by active medication, was an effective treatment for patients diagnosed as having quite severe symptoms of GAD. CLINICAL IMPLICATIONS AND LIMITATIONS: Dropouts led to a sample size which may have been too small to detect group differences. Cognitive therapy may have been more effective.
很少有研究探讨药物与心理治疗相结合用于广泛性焦虑症（GAD）的情况。从理论上讲，丁螺环酮应该是一种可与基于学习的疗法联合使用的有效药物。
60例广泛性焦虑症患者被随机分配接受丁螺环酮或安慰剂治疗，并联合焦虑管理训练或非指导性治疗，为期8周。
44例平均汉密尔顿焦虑量表评分为28分的患者完成了治疗。各治疗组之间无显著差异。与基线相比，所有组在8周后均有显著改善。完成试验者与未完成试验者在基线时无差异，但接受丁螺环酮治疗的患者更有可能退出。
短期心理治疗，无论是否伴有积极的药物治疗，对被诊断为有相当严重广泛性焦虑症症状的患者都是一种有效的治疗方法。临床意义和局限性：退出导致样本量可能过小，无法检测组间差异。认知疗法可能更有效。
