Sönmez Emine, Sönmez Ali Suha, Bayindir Yaşar, Coskun Diler, Aritürk Sedat
Department of Infectious Diseases and Clinical Microbiology, Medical Faculty of Kadir Has University, Vefabey Sokak No 5, 80 810 Gayrettepe, Istanbul, Turkey.
Vaccine. 2002 Dec 13;21(3-4):243-6. doi: 10.1016/s0264-410x(02)00452-8.
In this prospective study, our aim was to test the effect of simultaneous administration of preS2 and S containing recombinant hepatitis B vaccine (S2SRHB) with tetanus toxoid (TT) to the individuals who did not respond after three doses of hepatitis B vaccine previously. There were three groups (healthy individuals, pregnant women, hemodialysis patients), each was divided into two subgroups as groups A and B. Group A received S2SRHB+TT and group B received only S2SRHB. We found that in groups receiving both vaccines, both seroconversion rate and antibody titer level were significantly higher (P<0.05). In conclusion, simultaneous administration of S2SRHB+TT is more effective than administration of S2SRHB alone.
在这项前瞻性研究中，我们的目的是测试对先前接种三剂乙肝疫苗后无反应的个体同时接种含前S2和S的重组乙肝疫苗（S2SRHB）和破伤风类毒素（TT）的效果。研究分为三组（健康个体、孕妇、血液透析患者），每组再分为A组和B组两个亚组。A组接受S2SRHB+TT，B组仅接受S2SRHB。我们发现，在同时接种两种疫苗的组中，血清转化率和抗体滴度水平均显著更高（P<0.05）。总之，同时接种S2SRHB+TT比单独接种S2SRHB更有效。
