Da Villa G, Picciotto L, Ribera G, Bencivenga M, Cotugno M, Hartmann P
Italian Institute for Prevention of Liver Diseases, Naples.
Vaccine. 1995 Jun;13(9):795-8. doi: 10.1016/0264-410x(94)00069-y.
The antibody responses of Maldivian infants early in their life to simultaneous immunization against hepatitis B virus, poliomyelitis, diphtheria and tetanus were investigated. The vaccines were given at 6, 10 and 14 weeks of age. Among 243 newborn babies from HBsAg-negative mothers, 103 received three doses of oral poliomyelitis (OPV) and diphtheria and tetanus (DTV) vaccines; 105 were similarly immunized but received in addition the recombinant hepatitis B vaccine (HBV); 35 were immunized with the HBV recombinant vaccine alone. The antibody response to all of the vaccines was effective. No significant differences among the groups were observed. Hepatitis B vaccination of infants neither affected nor was affected by the contemporary administration of OPV and DTV vaccines.
对马尔代夫婴儿在其生命早期同时接种乙肝病毒、脊髓灰质炎、白喉和破伤风疫苗后的抗体反应进行了调查。疫苗在6周、10周和14周龄时接种。在243名母亲乙肝表面抗原阴性的新生儿中，103名接受了三剂口服脊髓灰质炎疫苗（OPV）和白喉破伤风疫苗（DTV）；105名接受了类似的免疫接种，但另外还接种了重组乙肝疫苗（HBV）；35名仅接种了HBV重组疫苗。对所有疫苗的抗体反应都是有效的。各组之间未观察到显著差异。婴儿接种乙肝疫苗既不影响同时接种的OPV和DTV疫苗，也不受其影响。
