Doman Glenn, Pelligra Ralph
The Insitutes for the Achievement of Human Potential, Wyndmoor, USA.
Med Hypotheses. 2003 Jan;60(1):129-32. doi: 10.1016/s0306-9877(02)00348-1.
Seizure (ictal) behavior in humans has been observed and recorded since ancient times. A satisfactory solution to this vexing problem continues to elude medical science. Antiepileptic drug (AED) therapy fails to control seizures in 20% of patients with primary generalized epilepsy and 35% of patients with partial epilepsy and has many side effects, including death. This paper cites evidence from the current literature that supports a plausible hypothesis of seizure genesis that was published in 1942, but somehow escaped recognition. It presents a concept that challenges contemporary thinking and may provide the basis for a much needed paradigm shift in the understanding of the nature of seizures and an approach to their management. The theory views a seizure as a natural reflex defense response to a lethal threat to the brain. Although capable of inflicting bodily injury due to falls, drowning, etc., the seizure is not considered inherently harmful to the brain and may be associated with beneficial circulatory changes. Efforts to control and prevent seizures should be directed away from pharma-chemical suppression towards developing methods and bioactive agents that promote neuroplasticity, neurogenesis, and an optimized physiological milieu within the brain.
自古以来，人类的癫痫发作（发作期）行为就已被观察和记录。医学科学至今仍未能找到解决这个棘手问题的令人满意的办法。抗癫痫药物（AED）治疗在20%的原发性全身性癫痫患者和35%的部分性癫痫患者中无法控制癫痫发作，并且有许多副作用，包括死亡。本文引用了当前文献中的证据，这些证据支持了一个在1942年发表但不知为何未被认可的关于癫痫发作起源的似是而非的假说。它提出了一个挑战当代思维的概念，并可能为在理解癫痫本质及其治疗方法上急需的范式转变提供基础。该理论将癫痫发作视为对大脑致命威胁的一种自然反射防御反应。尽管癫痫发作可能因跌倒、溺水等造成身体伤害，但它本身并不被认为对大脑有害，而且可能与有益的循环变化有关。控制和预防癫痫发作的努力应从药物化学抑制转向开发促进神经可塑性、神经发生以及大脑内优化生理环境的方法和生物活性物质。
