Philipson A, Sabath L D, Charles D
Clin Pharmacol Ther. 1976 Jan;19(1):68-77. doi: 10.1002/cpt197619168.
Thirty-nine pregnant women admitted for therapeutic abortions during early or mid pregnancy were given erythromycin estolate, erythromycin base, or clindamycin hydrochloride orally in single or multiple doses. Peak serum levels of clindamycin were 3.4 to 9.0 mug/ml following a single dose of 450 mg, whereas peak serum levels of erythromycin were 0.29 to 7.2 mug/ml following 500 mg in a single dose. The individual variability of serum concentrations of erythromycin was greater than that reported in normal men and nonpregnant women, whereas the serum levels of clindamycin were rather uniform, and similar to what has been reported in nonpregnant individuals. Following multiple doses of each antibiotic, high serum levels were obtained in virtually all subjects, and urine levels were also higher. Following single doses the mean urinary recovery was 2% for erythromycin and 16.8% for clindamycin.
三十九名在妊娠早期或中期因治疗性流产而入院的孕妇，分别单次或多次口服无味红霉素、红霉素碱或盐酸克林霉素。单次服用450毫克盐酸克林霉素后，血清峰值水平为3.4至9.0微克/毫升，而单次服用500毫克红霉素后的血清峰值水平为0.29至7.2微克/毫升。红霉素血清浓度的个体差异大于正常男性和非孕妇的报道，而克林霉素的血清水平相当一致，与非孕妇个体的报道相似。每种抗生素多次给药后，几乎所有受试者的血清水平都很高，尿液水平也较高。单次给药后，红霉素的平均尿回收率为2%，克林霉素为16.8%。
