Bystedt H, DAhlbäck A, Dornbusch K, Nord C E
Int J Oral Surg. 1978 Oct;7(5):442-9. doi: 10.1016/s0300-9785(78)80035-0.
Postoperative complications after surgery in the mandible are still a clinical problem. Levels of four antibiotics--azidocillin, erythromycin, doxycycline and clindamycin--were measured in serum, dental alveolar serum, saliva and mandibular bone in 24 patients undergoing surgical removal of mandibular third molars. The concentration in mandibular bone for azidocillin was 0.8 microgram/g +/- 0.4 microgram/g, erythromycin 0.2 microgram/g +/- 0.1 microgram/g, doxycycline 2.6 microgram/g +/- 2 microgram/g and clindamycin 0.6 microgram/g +/- 0.4 microgram/g. No saliva levels were achieved with azidocillin and erythromycin, whereas doxycycline and clindamycin gave measurable saliva levels.
下颌骨手术后的术后并发症仍是一个临床问题。对24例接受下颌第三磨牙手术摘除的患者，测定了血清、牙槽血清、唾液和下颌骨中四种抗生素——叠氮西林、红霉素、强力霉素和克林霉素的含量。叠氮西林在下颌骨中的浓度为0.8微克/克±0.4微克/克，红霉素为0.2微克/克±0.1微克/克，强力霉素为2.6微克/克±2微克/克，克林霉素为0.6微克/克±0.4微克/克。叠氮西林和红霉素在唾液中未检测到含量，而强力霉素和克林霉素在唾液中可检测到含量。
