Suzuki Motohisa
Bayer Medical Ltd., Shibuya-ku, Tokyo 150-0013.
Rinsho Byori. 2002 Oct;50(10):953-7.
This paper introduces Point-Of-Care Testing(POCT) developed by Bayer, mainly focusing on urine dipstick and tests for Diabetes Mellitus. Urinalysis using a dipstick has been widely carried out as a screening test for various kinds of diseases. Ten-pad urine dipstick is commercially available at the present time, and the desktop instruments have been developed for automatic optical reading, such as the Clinitek 50/100/500 systems. More recently, Bayer developed a new urine dipstick intended for reliable detection of the early stage of kidney disease without the influence of urine condensation or dilution. The dipstick adds 2 pads to conventional urine dipsticks: one for the measurement of small amounts of protein(albumin), and the other for creatinine. A semi-quantitative urine protein-to-creatinine ratio is based on these results. There have been significant advances made in blood glucose meters for POCT in terms of reliability, simplicity of operation, sample volume, etc. And not only healthcare professionals but also patients with diabetes have used POCT meters. Dexter-ZII is available as one of these meters. DCA2000 is a portable analyzer for measuring HbA1c in 6 min. Patients could be treated and instructed on the basis of HbA1c measured by DCA2000. As one of the tasks for the future, it is preferable that some POCT systems be available as OTC for ordinary people to manage their own health. Also, I emphasize that it is important to review the usability of conventional urine dipsticks like a check for drug side effects, as well as for developing new urine analyses.
本文介绍了拜耳公司开发的即时检验（POCT），主要聚焦于尿试纸条及糖尿病检测。使用尿试纸条进行尿液分析已广泛用作各类疾病的筛查测试。目前市面上有十项试纸条在售，并且已开发出桌面型仪器用于自动光学读取，如Clinitek 50/100/500系统。最近，拜耳公司开发了一种新型尿试纸条，旨在不受尿液浓缩或稀释影响可靠检测肾病早期阶段。该试纸条在传统尿试纸条基础上增加了两个检测区：一个用于测量少量蛋白质（白蛋白），另一个用于测量肌酐。基于这些结果得出半定量尿蛋白与肌酐比值。在即时检验的血糖仪方面，在可靠性、操作简便性、样本量等方面取得了重大进展。不仅医疗专业人员，糖尿病患者也使用即时检验血糖仪。Dexter-ZII就是其中一款血糖仪。DCA2000是一款便携式分析仪，可在6分钟内测量糖化血红蛋白（HbA1c）。可根据DCA2000测量的HbA1c对患者进行治疗和指导。作为未来的任务之一，最好有一些即时检验系统作为非处方药供普通人管理自身健康。此外，我强调，像检查药物副作用一样审查传统尿试纸条的可用性以及开发新的尿液分析方法很重要。
