Cubo E, Rojo A, Ramos S, Quintana S, Gonzalez M, Kompoliti K, Aguilar M
Neurology Department, Hospital Mutua de Terrassa, Terrassa (Barcelona), Spain.
Eur J Neurol. 2002 Nov;9(6):589-93. doi: 10.1046/j.1468-1331.2002.00484.x.
To define the factors correlated with quality of life (QoL) in patients with idiopathic Parkinson's disease (PD).
PD has a substantial impact on QoL. Although several clinical factors have been associated with QoL in PD, the influence of patient's education still remains controversial.
A consecutive series of patients with PD were examined using the unified Parkinson's Disease Rating Scale (UPDRS part I, II, III), Schwab and England (SE), and Hoehn and Yahr stage (H&Y). QoL was rated with the PDQ-39, cognition with the Mini-Mental State examination (MMSE), and the presence of depressive symptoms with the geriatric depression scale (GDS). Patient's characteristics, estimated cumulative levodopa dose (CLD), UPDRS, H&Y, MMSE and GDS were correlated with the PDQ-39 using univariate and multiple regression analysis.
A total of one hundred 58 patients (68 men, 90 women) with a mean age of 65.6 +/- 9.3 years, PD duration of 8.1 +/- 10.6 years, and education of 6.6 +/- 3.9 years were included. The mean PDQ-39 was 48.8 +/- 27.8, mean MMSE was 25.7 +/- 4, and mean GDS was 11.7 +/- 6.8. Using stepwise multiple regression analysis, the most important predictive factors were depression, UPDRS part I, UPDRS part II, and educational background, which accounted for a 61% of the variability of the PDQ-39 scores.
In our PD sample, educational, behavioural, and psychological factors influenced life satisfaction more than physical ones.
确定特发性帕金森病（PD）患者生活质量（QoL）的相关因素。
PD对QoL有重大影响。虽然一些临床因素与PD患者的QoL有关，但患者教育程度的影响仍存在争议。
使用统一帕金森病评定量表（UPDRS第一、二、三部分）、施瓦布和英格兰量表（SE）以及霍恩和亚尔分期（H&Y）对一系列连续的PD患者进行检查。使用PDQ-39评估QoL，使用简易精神状态检查表（MMSE）评估认知，使用老年抑郁量表（GDS）评估抑郁症状的存在情况。通过单因素和多元回归分析，将患者特征、估计的左旋多巴累积剂量（CLD）、UPDRS、H&Y、MMSE和GDS与PDQ-39进行相关性分析。
共纳入158例患者（68例男性，90例女性），平均年龄65.6±9.3岁，PD病程8.1±10.6年，受教育年限6.6±3.9年。PDQ-39的平均值为48.8±27.8，MMSE的平均值为25.7±4，GDS的平均值为11.7±6.8。通过逐步多元回归分析，最重要的预测因素是抑郁、UPDRS第一部分、UPDRS第二部分和教育背景，它们占PDQ-39评分变异性的61%。
在我们的PD样本中，教育、行为和心理因素对生活满意度的影响大于身体因素。
