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Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.

作者信息

Rosen Rachel, Integlia Mark J, Bousvaros Athos

机构信息

Division of Pediatric Gastroenterology and Inflammatory Bowel Disease Center, Boston Children's Hospital, Boston, Massachusetts, USA.

出版信息

J Pediatr Gastroenterol Nutr. 2002 Nov;35(5):695-9. doi: 10.1097/00005176-200211000-00021.

DOI:10.1097/00005176-200211000-00021
PMID:12454589
Abstract
摘要

相似文献

1
Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.硫嘌呤甲基转移酶缺乏导致的严重全血细胞减少:克罗恩病患儿接受6-巯基嘌呤治疗可预防的并发症
J Pediatr Gastroenterol Nutr. 2002 Nov;35(5):695-9. doi: 10.1097/00005176-200211000-00021.
2
Normal thiopurine methyltransferase levels do not eliminate 6-mercaptopurine or azathioprine toxicity in children with inflammatory bowel disease.正常的硫嘌呤甲基转移酶水平并不能消除炎症性肠病患儿的6-巯基嘌呤或硫唑嘌呤毒性。
J Clin Gastroenterol. 2000 Jun;30(4):409-13. doi: 10.1097/00004836-200006000-00011.
3
TPMT in the treatment of Crohn's disease with azathioprine.硫嘌呤甲基转移酶在硫唑嘌呤治疗克罗恩病中的应用。
Gut. 2002 Aug;51(2):143-6. doi: 10.1136/gut.51.2.143.
4
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.一名自身免疫性肝炎患者因硫嘌呤甲基转移酶缺乏导致硫唑嘌呤引起的骨髓抑制。
J Hepatol. 1995 Sep;23(3):351-4. doi: 10.1016/0168-8278(95)80481-1.
5
Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase.硫唑嘌呤诱发的脓疱病患者全血细胞减少及红细胞硫嘌呤甲基转移酶缺乏
BMJ. 2005 Feb 12;330(7487):350-1. doi: 10.1136/bmj.330.7487.350.
6
Azathioprine, 6-mercaptopurine and thiopurine S-methyltransferase.硫唑嘌呤、6-巯基嘌呤与硫嘌呤甲基转移酶
J Gastroenterol Hepatol. 2005 Jun;20(6):955. doi: 10.1111/j.1440-1746.2005.03964.x.
7
Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency.一名患有克罗恩病且硫嘌呤甲基转移酶缺乏的患者发生与硫唑嘌呤相关的急性髓系白血病。
Am J Hematol. 2008 Jan;83(1):80-3. doi: 10.1002/ajh.21014.
8
Monitoring of azathioprine/6-mercaptopurine treatment in children with IBD is not necessary.对患有炎症性肠病的儿童进行硫唑嘌呤/6-巯基嘌呤治疗监测并无必要。
Inflamm Bowel Dis. 2003 Nov;9(6):389-91; discussion 392-3. doi: 10.1097/00054725-200311000-00008.
9
Dosing azathioprine in thiopurine S-methyltransferase deficient inflammatory bowel disease patients.硫嘌呤甲基转移酶缺乏的炎症性肠病患者中硫唑嘌呤的给药
Gut. 2008 Jun;57(6):872. doi: 10.1136/gut.2007.145912.
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Azathioprine-induced pancytopenia in homozygous thiopurine methyltransferase-deficient renal transplant recipients: a family study.纯合子硫嘌呤甲基转移酶缺陷型肾移植受者中硫唑嘌呤诱导的全血细胞减少症:一项家族研究
Transplant Proc. 1995 Apr;27(2):1739-42.

引用本文的文献

1
Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis.克罗恩病、硫嘌呤类药物和原发性 EBV 感染与噬血细胞性淋巴组织细胞增生症的关联。
J Pediatr. 2011 Nov;159(5):808-12. doi: 10.1016/j.jpeds.2011.04.045. Epub 2011 Jun 30.
2
Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing.硫唑嘌呤在炎症性肠病中的治疗:临床药理学及药物基因组学指导给药的意义
Clin Pharmacokinet. 2007;46(3):187-208. doi: 10.2165/00003088-200746030-00001.