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微阵列数据库:标准与本体论。

Microarray databases: standards and ontologies.

作者信息

Stoeckert Christian J, Causton Helen C, Ball Catherine A

机构信息

Center for Bioinformatics and Department of Genetics, University of Pennsylvania, 423 Guardian Drive, Philadelphia, Pennsylvania 19104-6021, USA.

出版信息

Nat Genet. 2002 Dec;32 Suppl:469-73. doi: 10.1038/ng1028.

Abstract

A single microarray can provide information on the expression of tens of thousands of genes. The amount of information generated by a microarray-based experiment is sufficiently large that no single study can be expected to mine each nugget of scientific information. As a consequence, the scale and complexity of microarray experiments require that computer software programs do much of the data processing, storage, visualization, analysis and transfer. The adoption of common standards and ontologies for the management and sharing of microarray data is essential and will provide immediate benefit to the research community.

摘要

一张微阵列芯片就能提供数万个基因的表达信息。基于微阵列的实验所产生的信息量非常大,以至于任何一项单独的研究都无法挖掘出每一条科学信息。因此,微阵列实验的规模和复杂性要求计算机软件程序承担大量的数据处理、存储、可视化、分析和传输工作。采用通用标准和本体来管理和共享微阵列数据至关重要,这将立即给研究群体带来益处。

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