Espinet Blanca, Larriba Itziar, Salido Marta, Florensa Lourdes, Woessner Soledad, Sans-Sabrafen Jordi, Barranco Carles, Serrano Sergi, Solé Francesc
Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Escola de Citologia Hematològica Soledad Woessner-IMAS, Barcelona, Spain.
Hum Pathol. 2002 Nov;33(11):1145-8. doi: 10.1053/hupa.2002.129209.
Paraimmunoblastic variant of small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) is characterized by a diffuse proliferation of cells, called paraimmunoblasts, normally located on the pseudoproliferation centers. Patients usually present with multiple lymphadenopathies and a rapid and aggressive progression of the disease. We report a case with paraimmunoblastic variant of SLL/CLL genetically well-characterized by conventional cytogenetics, comparative genomic hybridization (CGH), IgH/BCL-1, IgH/BCL-2, and p53 fluorescent in situ hybridization (FISH) probes and polymerase chain reaction (PCR) for detection of IgH/BCL-2 translocation. A complex karyotype was found, with p53 deletion confirmed by CGH and FISH; however, no translocations involving either BCL-2 or BCL-1 and the immunoglobulin heavy chain gene were identified. A literature review shows only 20 previously reported cases, 6 of which involve genetic studies.
