Suzuki T, Nakaya M, Itoh Z, Tatemoto K, Mutt V
Gastroenterology. 1983 Jul;85(1):114-21.
The inhibitory effect of peptide YY on contractile activity in the innervated main stomach and the vagally denervated fundic pouch in conscious Heidenhain pouch dogs was investigated. Peptide YY was given in i.v. bolus injections of doses between 12.5 and 100 pmol/kg body wt. During the digestive state, 2-3 h after feeding, peptide YY was found to have no effect on contractile activity in either the innervated or the vagally denervated stomach. In the interdigestive state, it was found that peptide YY inhibited the interdigestive migrating contractions in the innervated main stomach dose-dependently for 1.2 +/- 0.1 to 5.8 +/- 0.3 min, but did not affect pouch contractions at all. This peptide, however, did not influence the cycle of the interdigestive migrating contractions. Pentagastrin, on the other hand, suppressed the interdigestive migrating contractions in the innervated main stomach when the bolus doses were greater than 300 pmol/kg body wt, but did not inhibit pouch contractions completely with this dose. Atropine (0.05 mg/kg body wt) suppressed contractions in both the main stomach and the vagally denervated pouch. Peptide YY inhibits the interdigestive migrating contractions in the stomach through the extrinsic nerves.
研究了肽YY对海登海因小胃犬清醒状态下支配的主胃和迷走神经切断的胃底袋收缩活动的抑制作用。肽YY以12.5至100 pmol/kg体重的静脉推注剂量给药。在消化状态下，喂食后2 - 3小时，发现肽YY对支配的或迷走神经切断的胃的收缩活动均无影响。在消化间期状态下，发现肽YY剂量依赖性地抑制支配的主胃中的消化间期移行性收缩1.2±0.1至5.8±0.3分钟，但对胃袋收缩完全没有影响。然而，这种肽并不影响消化间期移行性收缩的周期。另一方面，当推注剂量大于300 pmol/kg体重时，五肽胃泌素抑制支配的主胃中的消化间期移行性收缩，但此剂量不能完全抑制胃袋收缩。阿托品（0.05 mg/kg体重）抑制主胃和迷走神经切断的胃袋的收缩。肽YY通过外在神经抑制胃中的消化间期移行性收缩。
