Pablo G M, Fulton J E
Arch Dermatol. 1975 Jun;111(6):734-5. doi: 10.1001/archderm.111.6.734.
Various tetracyclines and erythromycins have been used rather empirically for the systemic treatment of acne vulgaris for more than a decade. It has been impossible to accurately evaluate clinically the numerous derivatives and to compare their effectiveness with other antibiotics such as clindamycin. As a substitute for this approach, this present study ranks these antibiotics, when given orally, as to their effectivensss in suppressing the fatty acids in sebum in normal volunteers. As a group, the tetracyclines were more effective than the erythromycins in decreasing the fatty acids, but clindamycin was significantly more potent than either.
十多年来，各种四环素类和红霉素类药物一直被凭经验用于寻常痤疮的全身治疗。临床上不可能准确评估众多衍生物，也无法将它们的疗效与克林霉素等其他抗生素进行比较。作为这种方法的替代方案，本研究对这些抗生素口服时抑制正常志愿者皮脂中脂肪酸的效果进行了排序。总体而言，四环素类在降低脂肪酸方面比红霉素类更有效，但克林霉素的效力明显高于这两者。
