Del Rosso James Q, Armillei Maria K, Lomakin Ivan B, Grada Ayman, Bunick Christopher G
Dr. Del Rosso is Adjunct Clinical Faculty in Dermatology at Touro University Nevada in Henderson, Nevada, JDR Dermatology Research in Las Vegas, Nevada, and Advanced Dermatology and Cosmetic Surgery in Maitland, Florida.
Ms. Armillei is with the Translational Biomedicine Program at the Yale University School of Medicine in New Haven, Connecticut.
J Clin Aesthet Dermatol. 2024 Aug;17(8):29-40.
Clindamycin is a lincosamide antibiotic that has been used as a topical, oral, or injectable formulation for over five decades. It exhibits a narrow spectrum of microbiologic activity, primarily against gram-positive and anaerobic bacteria. In dermatology, clindamycin has been used primarily as a topical agent, usually for the treatment of acne vulgaris. Despite questions surrounding antibiotic resistance and/or its relative contribution to antibiotic treatment efficacy, a large body of data support the therapeutic value of topical clindamycin for acne vulgaris. As a systemic agent, clindamycin is used orally to treat a variety of cutaneous bacterial infections, and sometimes for acne vulgaris, with oral treatment for the latter less common in more recent years. The modes of action of clindamycin are supported by data showing both its anti-inflammatory and antibiotic mechanisms, which are discussed here along with pharmacokinetic profiles and structure-activity relationships. The diverse applications of clindamycin for multiple disease states, its efficacy, and safety considerations are also reviewed here, including for both topical and systemic formulations. Emphasis is placed on uses in dermatology, but other information on clindamycin relevant to clinicians is also discussed.
克林霉素是一种林可酰胺类抗生素，五十多年来一直作为外用、口服或注射制剂使用。它具有较窄的微生物活性谱，主要针对革兰氏阳性菌和厌氧菌。在皮肤科，克林霉素主要用作外用制剂，通常用于治疗寻常痤疮。尽管存在抗生素耐药性问题和/或其对抗生素治疗效果的相对贡献存在疑问，但大量数据支持外用克林霉素治疗寻常痤疮的治疗价值。作为一种全身用药，克林霉素口服用于治疗多种皮肤细菌感染，有时也用于治疗寻常痤疮，近年来后者的口服治疗不太常见。克林霉素的作用方式有数据支持其抗炎和抗生素机制，在此将与药代动力学特征和构效关系一起进行讨论。本文还综述了克林霉素在多种疾病状态下的不同应用、疗效及安全性考量，包括外用和全身制剂。重点放在皮肤科的应用，但也讨论了与临床医生相关的克林霉素的其他信息。
