Kucera-Sliutz Elisabeth, Schiebel Ingrid, König Franz, Leodolter Sepp, Sliutz Gerhard, Koelbl Heinz
Department of Gynaecology and Obstetrics, University of Vienna, Waehringer-Guertel 18-20, Austria.
Hum Reprod. 2002 Dec;17(12):3231-4. doi: 10.1093/humrep/17.12.3231.
This study evaluated serum vascular endothelial growth factor (VEGF) levels in women with abnormal intrauterine and ectopic pregnancies (EP) at 6 weeks gestation.
We conducted a prospective case-control study comparing serum VEGF concentrations among 84 women with abnormal intrauterine and EP matched for gestational age (42 women in each group). We analysed whether serum VEGF levels >200 pg/ml would discriminate between abnormal intrauterine pregnancies and EP at 6 weeks gestation, and we calculated sensitivity, specificity and positive predictive values.
Serum VEGF concentrations did not show statistically significant differences between women with abnormal intrauterine pregnancies (median, 198.5 pg/ml; range, 0-701.6) and EP (median, 211.2 pg/ml; range 0-628.8). When threshold concentrations of a serum VEGF level >200 pg/ml were used, abnormal intrauterine pregnancy could be distinguished from EP with a sensitivity of 56%, a specificity of 51%, and a positive predictive value of 53%.
VEGF does not discriminate ectopic from abnormal intrauterine pregnancies at 6 weeks gestation, and thus should not be used in clinical management.
本研究评估了妊娠6周时宫内妊娠异常和异位妊娠（EP）女性的血清血管内皮生长因子（VEGF）水平。
我们进行了一项前瞻性病例对照研究，比较了84例孕周匹配的宫内妊娠异常和EP女性（每组42例）的血清VEGF浓度。我们分析了血清VEGF水平>200 pg/ml是否能在妊娠6周时区分宫内妊娠异常和EP，并计算了敏感性、特异性和阳性预测值。
宫内妊娠异常女性（中位数，198.5 pg/ml；范围，0 - 701.6）和EP女性（中位数，211.2 pg/ml；范围0 - 628.8）的血清VEGF浓度无统计学显著差异。当使用血清VEGF水平>200 pg/ml的阈值浓度时，区分宫内妊娠异常和EP的敏感性为56%，特异性为51%，阳性预测值为53%。
VEGF在妊娠6周时无法区分异位妊娠和宫内妊娠异常，因此不应在临床管理中使用。
