Daniel Y, Geva E, Lerner-Geva L, Eshed-Englender T, Gamzu R, Lessing J B, Bar-Am A, Amit A
Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Israel.
Fertil Steril. 1999 Dec;72(6):1013-7. doi: 10.1016/s0015-0282(99)00417-3.
To determine serum levels of vascular endothelial growth factor (VEGF) and evaluate their capacity to serve as a marker for the diagnosis of ectopic pregnancy (EP).
Prospective, case-controlled study.
A tertiary care center.
PATIENT(S): Twenty women with EP, 10 women with normal intrauterine pregnancy, and 10 women with abnormal intrauterine pregnancy, all at comparable stages of gestation.
INTERVENTION(S): Serum samples were obtained from all women.
MAIN OUTCOME MEASURE(S): All samples were analyzed for VEGF, progesterone, and beta-hCG by specific methods.
RESULT(S): Women with EP had higher serum levels of VEGF than women with normal intrauterine pregnancy and women with abnormal intrauterine pregnancy (median levels, 226.8 pg/mL, 24.4 pg/mL, and 59.4 pg/mL, respectively). With a cutoff level of 200 pg/mL, serum VEGF could distinguish intrauterine from extrauterine pregnancy with a sensitivity of 60%, specificity of 90%, and positive predictive value of 86%.
CONCLUSION(S): The increased serum VEGF levels in women with EP may facilitate this challenging diagnosis and reduce maternal morbidity and mortality.
测定血清血管内皮生长因子（VEGF）水平，并评估其作为异位妊娠（EP）诊断标志物的能力。
前瞻性病例对照研究。
三级医疗中心。
20例异位妊娠女性、10例宫内妊娠正常女性和10例宫内妊娠异常女性，所有患者妊娠阶段相当。
采集所有女性的血清样本。
采用特定方法对所有样本进行VEGF、孕酮和β - hCG分析。
异位妊娠女性的血清VEGF水平高于宫内妊娠正常女性和宫内妊娠异常女性（中位数水平分别为226.8 pg/mL、24.4 pg/mL和59.4 pg/mL）。血清VEGF以200 pg/mL为临界值时，区分宫内妊娠和宫外妊娠的灵敏度为60%，特异度为90%，阳性预测值为86%。
异位妊娠女性血清VEGF水平升高可能有助于这一具有挑战性的诊断，并降低孕产妇发病率和死亡率。
