一氧化氮揭秘
Demystified. Nitric oxide.
作者信息
Stuart-Smith K
机构信息
Department of Anaesthesia, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK.
出版信息
Mol Pathol. 2002 Dec;55(6):360-6. doi: 10.1136/mp.55.6.360.
Abstract
The discovery of nitric oxide (NO) demonstrated that cells could communicate via the manufacture and local diffusion of an unstable lipid soluble molecule. Since the original demonstration of the vascular relaxant properties of endothelium derived NO, this fascinating molecule has been shown to have multiple, complex roles within many biological systems. This review cannot hope to cover all of the recent advances in NO biology, but seeks to place the discovery of NO in its historical context, and show how far our understanding has come in the past 20 years. The role of NO in mitochondrial respiration, and consequently in oxidative stress, is described in detail because these processes probably underline the importance of NO in the development of disease.
摘要
一氧化氮（NO）的发现表明，细胞可以通过制造和局部扩散一种不稳定的脂溶性分子来进行通讯。自从最初证明内皮源性NO具有血管舒张特性以来，这个迷人的分子已被证明在许多生物系统中具有多种复杂的作用。本综述无法涵盖NO生物学的所有最新进展，而是试图将NO的发现置于其历史背景中，并展示在过去20年里我们的理解取得了多大的进展。详细描述了NO在线粒体呼吸以及因此在氧化应激中的作用，因为这些过程可能是NO在疾病发展中重要性的基础。
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