阐明TOR信号传导与雷帕霉素作用：来自酿酒酵母的经验教训。
Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae.
作者信息
Crespo José L, Hall Michael N
机构信息
Division of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
出版信息
Microbiol Mol Biol Rev. 2002 Dec;66(4):579-91, table of contents. doi: 10.1128/MMBR.66.4.579-591.2002.
Abstract
TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.
摘要
雷帕霉素靶蛋白（TOR）是一种磷脂酰肌醇激酶相关蛋白激酶，可根据营养物质来控制细胞生长。雷帕霉素是一种免疫抑制和抗癌药物，通过抑制TOR发挥作用。从酿酒酵母到人类，TOR和雷帕霉素的作用模式都显著保守。目前对TOR和雷帕霉素的认识很大程度上来自对酿酒酵母的研究。在这篇综述中，我们讨论了酿酒酵母对理解雷帕霉素作用和TOR功能所做的贡献。
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Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae.阐明TOR信号传导与雷帕霉素作用：来自酿酒酵母的经验教训。
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2
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Mol Cell Biol. 2002 Aug;22(15):5575-84. doi: 10.1128/MCB.22.15.5575-5584.2002.
3
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Proc Natl Acad Sci U S A. 2002 May 14;99(10):6784-9. doi: 10.1073/pnas.102687599. Epub 2002 May 7.
4
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Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6422-7. doi: 10.1073/pnas.092141899.
5
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Mol Biol Cell. 2002 Mar;13(3):795-804. doi: 10.1091/mbc.01-09-0473.
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8
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