Ryo U Y, Townley R G
J Allergy Clin Immunol. 1976 Jan;57(1):12-24. doi: 10.1016/0091-6749(76)90074-9.
Pulmonary functions, by means of FEV1, FVC, and airway resistance, and cardiovascular responses, i.e., ECG, blood pressure, and pulse contour, were measured in 10 control and 15 symptom-free asthmatic subjects during and after the infusions of isoproterenol, with or without previous administration of propranolol or practolol. Bronchial sensitivity to methacholine and response to isoproterenol after methacholine were also measured. Bronchial sensitivity to methacholine challenge was markedly enhanced by propranolol and the effect of isoproterenol infusion on the pulmonary function was also significantly diminished, whereas practolol did not reveal any effect on bronchial sensitivity to methacholine or isoproterenol. The above changes were much more profound in symptom-free asthmatic subjects than in control subjects. The results suggest that practolol does not significantly affect the beta-2 bronchial receptors, is safe to use in asthmatic subjects, and is consistent with an abnormality of these receptors in bronchial asthma.
在10名对照受试者和15名无症状哮喘受试者中，于输注异丙肾上腺素期间及之后，无论是否预先给予普萘洛尔或普拉洛尔，均通过第一秒用力呼气量（FEV1）、用力肺活量（FVC）和气道阻力来测定肺功能，并通过心电图、血压和脉搏轮廓来测定心血管反应。还测定了对乙酰甲胆碱的支气管敏感性以及乙酰甲胆碱后对异丙肾上腺素的反应。普萘洛尔显著增强了对乙酰甲胆碱激发的支气管敏感性，且输注异丙肾上腺素对肺功能的影响也显著减弱，而普拉洛尔对乙酰甲胆碱或异丙肾上腺素的支气管敏感性未显示任何影响。上述变化在无症状哮喘受试者中比在对照受试者中更为显著。结果表明，普拉洛尔不会显著影响β2支气管受体，在哮喘受试者中使用安全，且与支气管哮喘中这些受体的异常情况相符。
