脂氧合酶产物作为气道平滑肌反应性调节剂的潜在作用。
A possible role for lipoxygenase products as regulators of airway smooth muscle reactivity.
作者信息
Adcock J J, Garland L G
出版信息
Br J Pharmacol. 1980 Jun;69(2):167-9. doi: 10.1111/j.1476-5381.1980.tb07886.x.
Abstract
The size of guinea-pig isolated tracheal contractions induced by histamine was substantially augmented by pretreatment with the cyclo-oxygenase inhibitor, indomethacin. However, compounds which inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism not only did not augment histamine-induced contractions of the guinea-pig trachea, but also completely reversed the increased reactivity to histamine produced by indomethacin. The SRS-A (slow reacting substance of anaphylaxis) antagonist, FPL55712, and the anti-allergic drug, cromoglycate, had no effect on the augmentation of histamine-induced contractions by indomethacin.
摘要
用环氧化酶抑制剂吲哚美辛预处理后，组胺诱导的豚鼠离体气管收缩幅度显著增大。然而，抑制花生四烯酸代谢中环氧化酶和脂氧合酶途径的化合物不仅没有增强组胺诱导的豚鼠气管收缩，反而完全逆转了吲哚美辛所产生的对组胺反应性的增加。过敏反应慢反应物质（SRS - A）拮抗剂FPL55712和抗过敏药物色甘酸对吲哚美辛增强组胺诱导的收缩没有影响。
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Br Med J. 1973 Jan 27;1(5847):193-6. doi: 10.1136/bmj.1.5847.193.
2
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Nat New Biol. 1973 Oct 17;245(146):215-7. doi: 10.1038/newbio245215a0.
3
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J Allergy Clin Immunol. 1976 Jan;57(1):12-24. doi: 10.1016/0091-6749(76)90074-9.
4
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J Pharmacol Exp Ther. 1975 Sep;194(3):554-64.
5
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