Schiaffino Stefano, Serrano AntonioL
Dept of Biomedical Sciences, CNR Institute of Neurosciences, University of Padova, Viale G. Colombo 3, Italy.
Trends Pharmacol Sci. 2002 Dec;23(12):569-75. doi: 10.1016/s0165-6147(02)02111-9.
Nerve activity controls muscle contractile function and muscle gene expression. Although excitation-contraction coupling is well characterized, excitation-transcription coupling is still poorly understood. Pharmacological and genetic approaches have been used to dissect the signaling pathways that mediate the effect of nerve activity on muscle fiber type and size. In particular, the role of calcineurin has recently been the subject of intensive investigation and debate. The identification of the transduction pathways involved in neuromuscular signaling has implications for the development of new therapeutic strategies to prevent muscle wasting and loss of muscle power resulting from aging, disuse and neuromuscular disorders.
神经活动控制肌肉收缩功能和肌肉基因表达。尽管兴奋-收缩偶联已得到充分表征，但兴奋-转录偶联仍知之甚少。药理学和遗传学方法已被用于剖析介导神经活动对肌纤维类型和大小影响的信号通路。特别是，钙调神经磷酸酶的作用最近一直是深入研究和争论的主题。确定参与神经肌肉信号传导的转导途径对于开发新的治疗策略具有重要意义，这些策略可预防因衰老、废用和神经肌肉疾病导致的肌肉萎缩和肌肉力量丧失。
