Zappulla Jacques P, Arock Michel, Mars Lennart T, Liblau Roland S
INSERM U546, Pitié Salpêtrière Hospital, 105 Boulevard de l'Hôpital, 75634 Cedex 13, Paris, France.
J Neuroimmunol. 2002 Oct;131(1-2):5-20. doi: 10.1016/s0165-5728(02)00250-3.
Growing evidence suggests that mast cells (MCs) play a crucial role in the inflammatory process and the subsequent demyelination observed in patients suffering from multiple sclerosis (MS). Although no consensus exists on the role of mast cells in multiple sclerosis, recent results from animal models clearly indicate that these cells act at multiple levels to influence both the induction and the severity of disease. In addition to changing our views on the pathophysiology of multiple sclerosis, the concept that mast cells are critical for the outcome of the disease could have an important impact on the development of new therapeutic approaches.
越来越多的证据表明，肥大细胞（MCs）在多发性硬化症（MS）患者的炎症过程及随后出现的脱髓鞘中起关键作用。尽管对于肥大细胞在多发性硬化症中的作用尚无定论，但动物模型的最新研究结果清楚地表明，这些细胞在多个层面发挥作用，影响疾病的诱发和严重程度。除了改变我们对多发性硬化症病理生理学的看法外，肥大细胞对疾病转归至关重要这一概念可能会对新治疗方法的开发产生重要影响。
